Epilepsy. Depakene (valproic acid) is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures. Valproic acid and its analogs are hepatotoxic and are contraindicated in patients with hepatic disease or significant hepatic dysfunction. Use with extreme caution in patients with a prior history of hepatic disease. These highlights do not include all the information needed to use Depakote ER safely and effectively. See full prescribing information for Depakote ER. Divalproex sodium occurs as a white powder with a characteristic odor. Depakote tablets are for oral administration. Depakote tablets are supplied in three dosage strengths containing divalproex sodium equivalent to 125 mg, 250 mg, or 500 mg of valproic acid. For the Consumer. Applies to divalproex sodium: oral capsule delayed release, oral tablet delayed release, oral tablet extended release. Along with its needed effects, divalproex sodium (the active ingredient contained in Depakote) may cause some unwanted effects. Depakote is contraindicated in the following situations: • In pregnancy (see sections 4.4 and 4.6). • In women of childbearing potential unless the conditions of the pregnancy prevention programme are fulfilled (see sections 4.4 and 4.6). Bula completa do DEPAKOTE SPRINKLE você encontra no MedicinaNet. Para que serve, indicações, contraindicações, como usar / tomar, efeitos colaterais, posologia e outras informações importantes do medicamento. Leia a bula e tire suas dúvidas. Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. GEODON can be used to treat symptoms of schizophrenia and acute manic or mixed episodes associated with bipolar disorder. GEODON can also be used as maintenance treatment of bipolar disorder when added to lithium or valproate (Depakote® The Card is not valid for California residents whose prescriptions are covered in whole or in part by third-party insurance, a healthcare service plan, or other health coverage where a lower cost generic is available, unless applicable step therapy or prior authorization requirements have been completed.